https://www.timothyspellman.com/home daily 0.75 2019-12-30 https://images.squarespace-cdn.com/content/v1/573cc03cc2ea51f428cb5dd6/1470092977225-50P98KC41C7C07JVYJV3/image-asset.jpeg Home - Our Practice Description text. Proin gravida ex id consectetur lobortis. Aliquam ornare, velit vel faucibus dapibus, augue justo ullamcorper turpis. https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1577502206535-GJM94KMV8WBUMPHO0APH/IMG_5946.JPG Home https://www.timothyspellman.com/contact daily 0.75 2019-12-30 https://www.timothyspellman.com/home-1 daily 0.75 2020-01-10 https://images.squarespace-cdn.com/content/v1/5405e8dfe4b017ae41b45b77/1410801075545-QXNX5B4RP44YED6DA10B/10.jpg Home https://www.timothyspellman.com/about daily 0.75 2021-06-08 https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579051454994-9O8ARS1JV3J9K3RN0C8L/logos.png About https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579042415477-0FOV72XL6FTHDDCF44IS/IMG_5946.JPG About - About I’m a research neurobiologist focused on the physiological substrates of executive functioning within higher-order association areas of the brain. I use a range of tools, including optogenetics, chemogenetics, extra-cellular electrophysiology, 2-photon and light field imaging, calcium and voltage indicators, pharmacology, custom robotics, and advanced statistics to investigate how the coordinated activity of biological neural networks processes information. I am currently an Instructor in Neuroscience are Weill Cornell Medicine in the lab of Conor Liston, and I completed my Ph.D. with Joshua Gordon at Columbia University. timothyspellman@gmail.com tis2013@med.cornell.edu @timjspellman curriculum vitae https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1578970604555-56XTV7NW74AMIBSC8PVN/IMG_5946.JPG About https://www.timothyspellman.com/images daily 0.75 2021-06-08 https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579040040437-IK4GQWM5EF1L1COI2VGH/PFC-VMS.png Images - PFC-VMS Cell bodies Pyramidal cells in layers 2/3 and 5 of the prefrontal cortex send axonal projections to the ventromedial striatum (VMS). These neurons, as well as those projecting to the medial dorsal thalamus, are critically important for encoding feedback information about the outcome of each trial in order to guide responses on future trials. https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579187613130-LSLZRPSL9LMUY478J59G/RigsAndBoards.png Images - set-shifting task Custom-designed behavioral rigs, powered by custom-printed circuit boards, for high-throughput behavioral testing of serial extra-dimensional set-shifting. Mice receive odor and whisker cues on each trial and learn, through trial and error, which sensory modality to attend to for a reward. https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579039260145-BKN4B1VRU5ZPKC0YUSIJ/vHPC.png Images - VHPC-PFC Projections Pyramidal cells of the ventral hippocampus (VHPC) send axonal projections to the prefrontal cortex (PFC), and these direct inputs critically support the encoding of cues during spatial working memory. https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579039531875-KQQVESF3D79PCGVF2FN5/Picture1.png Images - PFC place coding A topological heat map of activity from an example PFC neuron during the spatial working memory task. Warmer colors and higher elevation signify elevated firing rate at a given point in the 2-dimensional environment. https://www.timothyspellman.com/publications daily 0.75 2021-06-09 https://www.timothyspellman.com/resources daily 0.75 2021-06-28 https://www.timothyspellman.com/about-2 daily 1.0 2023-01-04 https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579042415477-0FOV72XL6FTHDDCF44IS/IMG_5946.JPG About - About I’m a research neurobiologist focused on the physiological substrates of executive functioning within higher-order association areas of the brain. I use a range of tools, including optogenetics, chemogenetics, extra-cellular electrophysiology, 2-photon and light field imaging, calcium and voltage indicators, pharmacology, custom robotics, and advanced statistics to investigate how the coordinated activity of biological neural networks processes information. I am an Assistant Professor of Neuroscience at the University of Connecticut School of Medicine. Before that, I did postdoctoral research in Conor Liston’s lab at Weill Cornell Medicine, and I completed my Ph.D. with Joshua Gordon at Columbia University. timothyspellman@gmail.com tspellman@uchc.edu @timjspellman curriculum vitae https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1579051454994-9O8ARS1JV3J9K3RN0C8L/logos.png About https://images.squarespace-cdn.com/content/v1/5e06bcb8d89e7165b5947c53/1578970604555-56XTV7NW74AMIBSC8PVN/IMG_5946.JPG About https://www.timothyspellman.com/hiring daily 0.75 2022-06-06